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Nr opisu: nna^u^t^qCywińska A^w^x0000032801^zCywińska Anna^aBorecka Autorzy: , , , , . Tytuł czasopisma: Tytuł równoległy: BoreckaGarbaczSzarskaDziudaLorenzŁakomyLepionkaAnyżewskaBiałekBertrandtoriginal-article994294009994.3940860-021X003Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active menBiology of Sport20210860-021X2021/202210.5114/biolsport.2022.109957Bertrandt, JerzyBody Mass IndexFINAL_PUBLISHEDPeroxisome proliferator-activated receptors (PPARs) have unique functions in energy metabolism regulation but are also involved in regulation of the inflammatory process and obesity. The aim of this study was to analyse potential associations between polymorphisms of PPARA (rs1800206), PPARD (rs1053049; rs2267668) and PPARG (rs1801282) and overweight parameters. One hundred and sixty-six males, unrelated Caucasian military professionals, were recruited in the genetic case-control study conducted in the period 2016-2019. All the participants were aged 21-41 and had similar levels of physical activity. Body mass, height and body composition were measured. The participants were divided into two groups depending on their BMI (body mass index) and FMI (fat mass index). The control group consisted of people with BMI between 20.0 and 25.0 or FMI values ? 6, while the overweight group consisted of people with BMI of ? 25.0 or FMI values > 6. Genomic DNA was isolated from extracted buccal cells. All samples were genotyped using real-time polymerase chain reaction (real-time PCR). It was found that two polymorphisms rs2267668 and rs1053049 of the PPARD gene were significantly associated with BMI: SNP rs2267668 for the dominant (OR = 2.04, 95%CI 1.01-4.11, p-value = 0.04) model (A/G-G/G vs A/A). The likelihood of being overweight was over 2 times smaller for allele A. A relationship between the polymorphism of PPARG (rs1801282) and BMI was found for the overdominant (OR = 2.03, 95%CI 1.03-4.00, p-value = 0.04) model (C/G vs C/C-G/G). Significant associations were found in different models for PPARD, PPARG and PPARA genes with BMI. In SNP rs2267668 for the codominant genetic model (G/G vs A/A) (p-value = 0.04) and : Anna : Aleksandra : Ewa : Łukasz : Katarzyna : Roman : Tomasz : Anna : Agnieszka : Jerzy Władysław : Oryginalny artykuł naukowyACPartykuł w czasopiśmie polskim4.606IF : 998599140.0000140.000PUNKTACJA KBNPUNKTACJA MINISTERSTWALISTA FILADELFIJSKAIMPACT FACTOR140.000PUNKTACJA UWM : 009859.000 : Q : 003 : Vol. 38 : 2083-1862 : CC-BY-SA Charakterystyka merytoryczna: Język publikacji: Wskaźnik Impact Factor ISI: Punktacja ministerstwa: Praca recenzowana Słowa kluczowe: cka Anna^bAnna^c^d^e^f^g^h^i ^m_^n_^oBorecka Anna^pBorecka Anna^rBorecka^sAnna^u^t^qBorecka A^w^x0000017549^zBorecka Anna^aGarbacz Słowa kluczowe ang.: pionka Tomasz^bTomasz^c^d^e^f^g^h^i ^m_^n_^oLepionka Tomasz^pLepionka Tomasz^rLepionka^sTomasz^u^t^qLepionka T^w^x0000032446^zLepionka Tomasz^aAnyżewska Słowa kluczowe ang.: ; ;
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Autorzy: . Tytuł pracy: Tytuł pracy w innym języku: 1471-2261003Is body mass index (BMI) or body adiposity index (BAI) a better indicator to estimate body fat and selected cardiometabolic risk factors in adults with intellectual disabilities?BMC Cardiovascular Disorders20211471-22612020/202110.1186/s12872-021-01931-9intellectual disabilitiesFINAL_PUBLISHEDBackground: The BMI index cannot always be used in people with intellectual disabilities due to neuromuscular coordination disorders and psychological barriers that may hinder conventional body weight measurement. The study aimed to assess the usefulness of BMI and BAI in estimating obesity and body fat in people with intellectual disabilities. Methods: The first stage of the research involved 161 people with profound intellectual disabilities. Somatic parameters (BM, BH, WC, HC) were measured and BMI, BAI, WHR were calculated. Fifty seven persons with above-normal BMI and BAI were included in the second stage of the study and biochemical parameters were determined (TC, LDL-cholesterol, HDL-cholesterol, TG, GL). Results: According to both BMI and BAI classifications, most people were overweight or obese. A high correlation of %BF with BMI and BAI indices was observed (r = 0.78). The sensitivity of both indices was 95.65%. In groups with above-normal BMI and BAI, an upward trend was found for mean values of TC, LDL, TG, and GL, with a simultaneous downward trend for HDL. Statistically significant intergroup differences were recorded for TG and GL (p < 0.05) for both indices (BMI and BAI). Conclusions: Our research demonstrated that BAI is complementary to BMI and can be recommended for the estimation of body fat and cardiometabolic risks in people with intellectual disabilities. Due to the ease of measurement, BAI has high utility value.Body Mass Indexbody adiposity indexcardiometabolic risk : Q : 003 : Vol. 21 : CC-BY Tytuł równoległy: 1471-2261003 : Q : 003 Miejsce wydania: 1471-2261003Is body mass index (BMI) or body adiposity index (BAI) a better indicator to estimate body fat and selected cardiometabolic risk factors in adults with intellectual disabilities?BMC Cardiovascular Disorders20211471-22612020/202110.1186/s12872-021-01931-9intellectual disabilitiesFINAL_PUBLISHEDBackground: The BMI index cannot always be used in people with intellectual disabilities due to neuromuscular coordination disorders and psychological barriers that may hinder conventional body weight measurement. The study aimed to assess the usefulness of BMI and BAI in estimating obesity and body fat in people with intellectual disabilities. Methods: The first stage of the research involved 161 people with profound intellectual disabilities. Somatic parameters (BM, BH, WC, HC) were measured and BMI, BAI, WHR were calculated. Fifty seven persons with above-normal BMI and BAI were included in the second stage of the study and biochemical parameters were determined (TC, LDL-cholesterol, HDL-cholesterol, TG, GL). Results: According to both BMI and BAI classifications, most people were overweight or obese. A high correlation o Wydawca: Q003Vol. 21CC-BY Rok wydania: 2021-03-11, 09:02AT_PUBLICATION Charakterystyka formalna: Słowa kluczowe ang.: al disabilities. Somatic parameters (BM, BH, WC, HC) were measured and BMI, BAI, WHR were calculated. Fifty seven persons with above-normal BMI and BAI were included in the second stage of the study and biochemical parameters were determined (TC, LDL-cholesterol, HDL-cholesterol, TG, GL). Results: According to both BMI and BAI classifications, most people were overweight or obese. A high correlation of %BF with BMI and BAI indices was observed (r = 0.78). The sensitivity of both indices was 95.65%. In groups with above-normal BMI and BAI, an upward trend was found for mean values of TC, LDL, TG, and GL, with a simultaneous downward trend for HDL. Statistically significant intergroup differences were recorded for TG and GL (p < 0.05) for both indices (BMI and BAI). Conclusions: Our research demonstrated that BAI is complementary to BMI and can be recommended for the estimation of body fat and cardiometabolic risks in people with intellectual disabilities. Due to the ease of measurement, BAI has high utility value.^aBody Mass Index^abody adiposity index^acardiometabolic risk Słowa kluczowe ang.: ; Inne bazy podające opis:
ntellectual disabilities. Somatic parameters (BM, BH, WC, HC) were measured and BMI, BAI, WHR were calculated. Fifty seven persons with above-normal BMI and BAI were included in the second stage of the study and biochemical parameters were determined (TC, LDL-cholesterol, HDL-cholesterol, TG, GL). Results: According to both BMI and BAI classifications, most people were overweight or obese. A high correlation of %BF with BMI and BAI indices was observed (r = 0.78). The sensitivity of both indices was 95.65%. In groups with above-normal BMI and BAI, an upward trend was found for mean values of TC, LDL, TG, and GL, with a simultaneous downward trend for HDL. Statistically significant intergroup differences were recorded for TG and GL (p < 0.05) for both indices (BMI and BAI). Conclusions: Our research demonstrated that BAI is complementary to BMI and can be recommended for the estimation of body fat and cardiometabolic risks in people with intellectual disabilities. Due to the ease of measurement, BAI has high utility value.^aBody Mass Index^abody adiposity index^acardiometabolic risk