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Państwowej Szkoły Wyższej w Białej Podlaskiej

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Autorzy: , , 009899.000 Q 003 Vol. 13 CC-BY 009993.182 1999-4915 003 Efficacy of Tocilizumab Therapy in Different Subtypes of COVID-19 Cytokine Storm Syndrome Viruses 2021 1999-4915 2020/2021 10.3390/v13061067 monoclonal antibodies FINAL_PUBLISHED Background: Cytokine storm in COVID-19 is heterogenous. There are at least three subtypes: cytokine release syndrome (CRS), macrophage activation syndrome (MAS), and sepsis. Methods: A retrospective study comprising 276 patients with SARS-CoV-2 pneumonia. All patients were tested for ferritin, interleukin-6, D-Dimer, fibrinogen, calcitonin, and C-reactive protein. According to the diagnostic criteria, three groups of patients with different subtypes of cytokine storm syndrome were identified: MAS, CRS or sepsis. In the MAS and CRS groups, treatment results were assessed depending on whether or not tocilizumab was used. Results: MAS was diagnosed in 9.1% of the patients examined, CRS in 81.8%, and sepsis in 9.1%. Median serum ferritin in patients with MAS was significantly higher (5894 vs. 984 vs. 957 ng/mL, p < 0.001) than in those with CRS or sepsis. Hypofibrinogenemia and pancytopenia were also observed in MAS patients. In CRS patients, a higher mortality rate was observed among those who received tocilizumab, 21 vs. 10 patients (p = 0.043), RR = 2.1 (95% CI 1.0-4.3). In MAS patients, tocilizumab decreased the mortality, 13 vs. 6 patients (p = 0.013), RR = 0.50 (95% CI 0.25-0.99). Conclusions: Tocilizumab therapy in patients with COVID-19 and CRS was associated with increased mortality, while in MAS patients, it contributed to reduced mortality.ARDS cytokine strom syndrome inflammation, ARDS cytokine strom syndrome inflammation.
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Tytuł równoległy: 009993.1821999-4915003Efficacy of Tocilizumab Therapy in Different Subtypes of COVID-19 Cytokine Storm SyndromeViruses20211999-49152020/202110.3390/v13061067monoclonal antibodiesFINAL_PUBLISHEDBackground: Cytokine storm in COVID-19 is heterogenous. There are at : 009899.000 : Q : 003 : Vol. 13 : CC-BY
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