Bibliografia publikacji pracowników
Państwowej Szkoły Wyższej w Białej Podlaskiej
Baza tworzona przez Bibliotekę Akademii Bialskiej im. Jana Pawła II.
Zapytanie: NON-INVASIVE LUNG VENTILATION
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Streszczenie: Research on the comparative efficacy of artificial lung ventilation in the patients with sepsis and mild acute respiratory distress syndrome under various regimens is the issue of today. The actual view on the topic being diverse, in most scientists view further research is needed. The objective of the research has been to compare the treatment outcomes of the patients with severe neurotrauma, sepsis, and mild acute respiratory distress syndrome (ARDS), depending on whether forced ventilation with regulated volume or noninvasive ventilation (NIV) is used as the regimen of ventilation support. Materials and methods: Involved in the randomized multicenter research were 60 men (mean age 43.8+8.6 years) with craniocerebral trauma, sepsis, and mild ARDS. The patients were divided into 2 groups (30 men in each) using random distribution method. In group 1, synchronized intermittent mandatory ventilation (SIMV) with regulated volume was used, whereas in group 2 continuous positive airway pressure (?PAP) was applied. Excluded from the research were those with impairment of consciousness, unstable hemodynamics, and X-ray evidence of pneumonia. In SIMV forced ventilation, respiratory volume was based on 4-6 ml/kg, the plateau level not exceeding 30 mbar, 8 mbar positive end-expiratory pressure (PEEP) being applied. Non-invasive lung ventilation was performed at 8 mbar PEEP, up to 15 mbar support pressure, the maximum pressure not exceeding 30 mbar. Results: In comparison with invasive lung ventilation, application of non-invasive lung ventilation in the patients with severe craniocerebral trauma, sepsis, and mild ARDS has been shown to contribute to the improvement of disease course, revealing itself in 1.32 times leukocytosis decrease, 2 times reduction in the blood serum procalcitonin content, as well as in 5 and 3 times decrease in the incidence of ventilator-associated pneumonias and mortality rate, respectively. Conclusion: Our findings taken into consideration, it may be concluded that application of non-invasive lung ventilation in the patients with mild ARDS and sepsis is appropriate, this treatment technique decreasing both the risk of ventilator-associated pneumonias and mortality rate. It can be argued that the application of non-invasive lung ventilation reduces the activity of septic process.
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