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Bibliografia publikacji pracowników
Państwowej Szkoły Wyższej w Białej Podlaskiej

Baza tworzona przez Bibliotekę Akademii Bialskiej im. Jana Pawła II.


Zapytanie: OXYGEN METABOLISM
Liczba odnalezionych rekordów: 2



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Nr opisu: 0000041175
Autorzy: Oleksandr V. Oliynyk, Marta Rorat, Wojciech Barg.
Tytuł pracy: Oxygen metabolism markers as predictors of mortality in severe COVID-19
Tytuł czasopisma:
Szczegóły: 2021, Vol. 103, p. 452--456
p-ISSN: 1201-9712
e-ISSN: 1878-3511
Charakterystyka formalna: artykuł w czasopiśmie zagranicznym
Charakterystyka merytoryczna: artykuł oryginalny naukowy
Charakterystyka wg MNiSW: artykuł w czasopiśmie z IF (wykaz MEiN)
Język publikacji: ENG
Wskaźnik Impact Factor ISI: 12.074
Punktacja ministerstwa: 100.000
Słowa kluczowe ang.: COVID-19 ; ARDS ; oxygen metabolism ; determinants of mortality ; respiratory failure
https://www.sciencedirect.com/science/article/pii/S1201971220325352
DOI: 10.1016/j.ijid.2020.12.012
Streszczenie: Objective: To investigate the use of oxygen metabolism markers as predictors of mortality in patients withsevere coronavirus disease 2019 (COVID-19). Methods: A retrospective analysis was undertaken to compare the medical records of patients with severeCOVID-19 (53 deceased patients and 50 survivors). The survivors were selected from 222 records using arandom number generator. In addition, 28 individuals who considered themselves to be healthy and whohad no history of serious illness were included in the study for comparison. Oxygen saturation in arterialblood, oxygen saturation in central venous blood (ScvO2), arterial partial pressure of oxygen (PaO2),respiratory index (PaO2/fraction of inspired oxygen), oxygen delivery, oxygen consumption (VO2) andoxygen extraction (O2ER) were compared in all participants. The optimal cut-off point for each oxygenmetabolism marker in the prediction of mortality was determined based on the maximum value of theYouden Index in receiver operating characteristic curve analysis. Results: Significant differences in all studied oxygen metabolism markers were found between survivorscompared with deceased patients (p < 0.001). ScvO2, VO2and O2ER [area under curve (AUC) 1.0] were thestrongest predictors of mortality, and PaO2was the weakest predictor of mortality (AUC 0.81). ScvO2<29%, VO2>124.6 ml/min and O2ER >30.2% were identified as predictors of mortality in patients withCOVID-19.Conclusion: ScvO2, VO2 and O2ER are good predictors of mortality in critically ill patients with COVID-19.

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Nr opisu: 0000036505
Autorzy: Aleksandr Olyinyk, Anna Ślifirczyk, Marcin Ślifirczyk, Magdalena Nikoniuk, Mariusz Celiński, Dorota Domańska.
Tytuł pracy: Effect of a medicinal agent, possessing antioxidant and antihypoxant properties, on the state of oxygen homeostasis and lipid peroxidation under experimental pneumoconiosis in albino rats
Tytuł czasopisma:
Szczegóły: 2018, Vol. 8, no 2, p. 137--143
p-ISSN: 2083-1617
Charakterystyka formalna: artykuł w czasopiśmie polskim
Charakterystyka merytoryczna: artykuł oryginalny naukowy
Charakterystyka wg MNiSW: artykuł w czasopiśmie bez IF (wykaz MEiN)
Język publikacji: ENG
Punktacja ministerstwa: 6.000
Praca recenzowana
Słowa kluczowe ang.: experimental pneumoconiosis ; methodology of pneumoconiosis stimulation in albino rats ; lipid peroxidation ; oxygen metabolism ; ethylmethylhydroxypyridine succinate
Uwaga: Kopia dostępna w Sekcji Bibliometrii.
https://progressinhealthsciences.publisherspanel.com/resources/html/article/details?id=184031
DOI: 10.5604/01.3001.0012.8336
Streszczenie: Introduction: Pneumoconioses (Pc) are interstitial pulmonary diseases of professional genesis, caused by long-term inhalation of high dust concentrations. Pcafflict 26.6-53% of the workers, exposed to dust contamination. The major feature of Pc course is irrevocability and incurability. Purpose: The research of the effect of ethylmethyl hydroxypyridine succinate, possessing antioxidant and antihypoxant characteristics, on the oxygen metabolism, acid-alkaline state, and lipid peroxidation at the background of experimental pneumoconiosis in albino rats. Material and methods: Pneumoconiosis was simulated on 72 albino rats through endotracheal injection of black coal suspension, on our own modification of O. Yu. Nykolenko methodology. Results: Manifestations of experimental pneumoconiosis depended on the period of dust inhalation. Development of experimental pneumoconiosis was found to result in the decreased partial oxygen pressure in the arterial blood, compensated hyperventilation-induced respiratory alkalosis, and marked increase in lipid peroxidation activity that could be seen in the blood content of malondialdehyde, as well as of conjugated dienes and trienes. Conclusions: Application of ethylmethylhydroxy pyridine succinate in experimental pneumoconiosis has been found to improve oxygen metabolism, acid-alkaline state, and lipid peroxidation that is revealed in normalization of the partial oxygen pressure in the arterial blood, oxygen saturation of haemoglobin, index of bases' deficiency BE (Base-Excess), and in 1.6-2.0 decrease in the content of malondialdehyde, as well as of conjugated dienes and trienes.

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