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Nr opisu: uk^sOleg M.^u^t^qDemchuk O^w^x0000026083^zDemchuk Oleg M.^aKubiński Autorzy: , , . Tytuł pracy: Tytuł równoległy: ChwedczukFoll-JosselinRuchaudBachDemchukKubińskioriginal-article995633009995.7331420-3049003The Anti-Candida albicans gent 4-AN Ingibits Multiple Protein KinasesMolecules20191420-30492018/201910.3390/molecules24010153Czernik, SławomirCandida albicansKopia dostępna w Sekcji Bibliometrii.FINAL_PUBLISHEDSmall molecules containing quinone and/or oxime moieties have been found as promising anti-fungal agents. One of them is 4-AN, a recently reported potent anti-Candida compound, which inhibits the formation of hyphae, decreases the level of cellular phosphoproteome, and finally shows no toxicity towards human erythrocytes and zebrafish embryos. Here, further research on 4-AN is presented. The results revealed that the compound: (i) Kills Candida clinical isolates, including these with developed antibiotic resistance, (ii) affects mature biofilm, and (iii) moderately disrupts membrane permeability. Atomic force microscopy studies revealed a slight influence of 4-AN on the cell surface architecture. 4-AN was also shown to inhibit multiple various protein kinases, a characteristic shared by most of the ATP-competitive inhibitors. The presented compound can be used in novel strategies in the fight against candidiasis, and reversible protein phosphorylation should be taken into consideration as a target in designing these strategies.Tokarska-Rodak, MałgorzataarylcyanomethylenequinonesChwedczuk, Marta4-ANprotein kinasesantifungal agentatomic force microscopy : Marta : Béatrice : Sandrine : Stéphane : Oleg M. : Konrad : Oryginalny artykuł naukowyACZartykuł w czasopiśmie zagranicznym3.267IF : 998599140.0000140.000PUNKTACJA KBNPUNKTACJA MINISTERSTWALISTA FILADELFIJSKAIMPACT FACTOR100.000PUNKTACJA UWM : 009859.000 : Q : 003 : Vol. 24 : CC-BY Charakterystyka formalna: .^rDemchuk^sOleg M.^u^t^qDemchuk O^w^x0000026083^zDemchuk Oleg M.^aKubiński Słowa kluczowe ang.: uk^sOleg M.^u^t^qDemchuk O^w^x0000026083^zDemchuk Oleg M.^aKubiński Słowa kluczowe ang.: ;
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Nr opisu: aciej^bMaciej^c^d^e^f^g^h^i ^m_^n_^oMasłyk Maciej^pMasłyk Maciej^rMasłyk^sMaciej^u^t^qMasłyk M^w^x0000026085^zMasłyk MaciejJaneczko Monika Kubiński Konrad Martyna Aleksandra Muzyczka Angelika Boguszewska-Czubara Anna Czernik Sławomir^aoriginal-article^bOryginalny artykuł naukowyACZartykuł w czasopiśmie zagranicznym1.926IF^a996974^b99974925.0000025.000PUNKTACJA KBNPUNKTACJA MINISTERSTWALISTA FILADELFIJSKAIMPACT FACTOR20.000PUNKTACJA UWM^a009997.074^b009974.000^c009999.000^d009979.000201820182018,4-Naphthoquinone derivatives potently suppress Candida albicans growth, inhibit formation of hyp00000353430000001518AOartykuł oryginalny naukowyPUBLIKACJAPEŁNA PUBLIKACJAAAartykuł w czasopiśmie z IF (wykaz MNiSW)AFILIACJA PODANAENGhttp://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000700PRACA RECENZOWANA100^a0022-2615^bA^fA^gABC^hABC^iX^jXY^a001^b003^c2018-02-28, 10:03^d2020-07-02, 09:56^e3628769236^f3424029283^a1,4-Naphthoquinone derivatives potently suppress Candida albicans growth, inhibit formation of hyphae and show no toxicity toward zebrafish embryos^aJournal of Medical Microbiology^a2018^bVol. 67^cissue 4^dp. 598--609^a0022-2615^a2017/2018^a10.1099/jmm.0.000700^aTokarska, Rodak-Małgorzata^cy^aNaphthoquinones^aKopia dostępna w Sekcji Bibliometrii.^aFINAL_PUBLISHED^bCC-BY^cBEFORE_PUBLICATION^d2^eOPEN_JOURNAL^aPurpose. In this study, we applied various assays to find new activities of 1,4-naphthoquinone derivatives for potential anti-Candida albicans applications. Methodology. These assays determined (a) the antimicrobial effect on growth/cell multiplication in fungal cultures, (b) the effect on formation of hyphae and biofilm, (c) the influence on cell membrane integrity, (d) the effect on cell morphology using atomic force microscopy, and (e) toxicity against zebrafish embryos. We have demonstrated the activity of these compounds against different Candida species and clinical isolates of C. albicans. Key findings. 1,4-Naphthoquinones significantly affected fungal strains at 8-250mg-1 of MIC. Interestingly, at concentrations below MICs, the chemicals showed effectiveness in inhibition of hyphal formation and cell aggregation in Candida. Of note, atomic force microscopy (AFM) analysis revealed an influence of the compounds on cell morphological properties. However, at low concentrations (0.8-31.2 mg-1), it did not exert any evident toxic effects on zebrafish embryos. Conclusions. Our research has evidenced the effectiveness of 1,4-naphthoquinones as potential anti-Candida agents.^aChwedczuk, Marta^cy^aCandida albicans^ahyphae^abiofilm^aatomic force microscopy^azebrafish Autorzy: , , . Tytuł pracy w innym języku: Tokarska-RodakChwedczukDemchukGolczykMasłykoriginal-article996974009997.0740022-26150011,4-Naphthoquinone derivatives potently suppress Candida albicans growth, inhibit formation of hyphae and show no toxicity toward zebrafish embryosJournal of Medical Microbiology20180022-26152017/201810.1099/jmm.0.000700Tokarska, Rodak-MałgorzataNaphthoquinonesKopia dostępna w Sekcji Bibliometrii.FINAL_PUBLISHEDPurpose. In this study, we applied various assays to find new activities of 1,4-naphthoquinone derivatives for potential anti-Candida albicans applications. Methodology. These assays determined (a) the antimicrobial effect on growth/cell multiplication in fungal cultures, (b) the effect on formation of hyphae and biofilm, (c) the influence on cell membrane integrity, (d) the effect on cell morphology using atomic force microscopy, and (e) toxicity against zebrafish embryos. We have demonstrated the activity of these compounds against different Candida species and clinical isolates of C. albicans. Key findings. 1,4-Naphthoquinones significantly affected fungal strains at 8-250mg-1 of MIC. Interestingly, at concentrations below MICs, the chemicals showed effectiveness in inhibition of hyphal formation and cell aggregation in Candida. Of note, atomic force microscopy (AFM) analysis revealed an influence of the compounds on cell morphological properties. However, at low concentrations (0.8-31.2 mg-1), it did not exert any evident toxic effects on zebrafish embryos. Conclusions. Our research has evidenced the effectiveness of 1,4-naphthoquinones as potential anti-Candida agents.Chwedczuk, MartaCandida albicanshyphaebiofilmatomic force microscopyzebrafish : Małgorzata : Marta : Oleg M. : Hieronim : Maciej : Oryginalny artykuł naukowyACZartykuł w czasopiśmie zagranicznym1.926IF : 99974925.0000025.000PUNKTACJA KBNPUNKTACJA MINISTERSTWALISTA FILADELFIJSKAIMPACT FACTOR20.000PUNKTACJA UWM : 009974.000 : A : 003 : Vol. 67 : CC-BY Szczegóły: Miejsce wydania: Tokarska-RodakChwedczukDemchukGolczykMasłykoriginal-article996974009997.0740022-26150011,4-Naphthoquinone derivatives potently suppress Candida albicans growth, inhibit formation of hyphae and show no toxicity toward zebrafish embryosJournal of Medical Microbiology20180022-26152017/201810.1099/jmm.0.000700Tokarska, Rodak-MałgorzataNaphthoquinonesKopia dostępna w Sekcji Bibliometrii.FINAL_PUBLISHEDPurpose. In this study, we applied various assays to find new activities of 1,4-naphthoquinone derivatives for potential anti-Candida albicans applications. Methodology. These assays determined (a) the antimicrobial effect on growth/cell multiplication in fungal cultures, (b) the effect on formation of hyphae and biofilm, (c) the influence on cell membrane integrity, (d) the effect on cell morphology using atomic force microscopy, and (e) toxicity against zebrafish embryos. We have demonstrated the activity of these compounds against different Candida species and clinical isolates of C. albicans. Key findings. 1,4-Naphthoquinones significantly affected fungal strains at 8-250mg-1 of MIC. Interestingly, at concentrations below MICs, the chemicals showed effectiveness in inhibition of hyphal formation and cell aggregation in Candida. Of note, atomic force microscopy (AFM) analysis revealed an influence of the compounds on cell morphological properties. However, at low concentrations (0.8-31.2 mg-1), it did not exert any evident toxic effects on zebrafish embryos. Conclusions. Our research has evidenced the effectiveness of 1,4-naphthoquinones as potential anti-Candida agents.Chwedczuk, MartaCandida albicanshyphaebiofilmatomic force microscopyzebrafish Wydawca: SławomirMałgorzataMartaOleg M.HieronimMaciejOryginalny artykuł naukowyACZartykuł w czasopiśmie zagranicznym1.926IF99974925.0000025.000PUNKTACJA KBNPUNKTACJA MINISTERSTWALISTA FILADELFIJSKAIMPACT FACTOR20.000PUNKTACJA UWM009974.000A003Vol. 67CC-BY Rok wydania: 015019015009999.0002018-02-28, 10:03issue 4yBEFORE_PUBLICATIONy Charakterystyka formalna: Praca recenzowana Słowa kluczowe ang.: j_^k_^lCzernik Sławomir^pCzernik Sławomir^rCZERNIK^sSŁAWOMIR^u^tCentrum Badań nad Innowacjami^qCzernik S^w3967151^x0000019935^zCzernik Sławomir^aTokarska-Rodak Słowa kluczowe ang.: Uwaga: DOI:
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Autorzy: , , . Tytuł pracy w innym języku: KozakChwedczukKlewek998899009999.000001Changes in amino acid decarboxylation in maize (Zea mays; Poaceae) tissues in response to bird cherry-oat aphid (Rhopalosiphum padi; Aphididae) infestationBiochemical Systematics and Ecology20150305-197810.1016/j.bse.2015.04.017kukurydzamaizeKopia dostępna w Sekcji BibliometriiFINAL_PUBLISHEDThe study was focused on changes in the activities of ornithine decarboxylase (ODC), lysine decarboxylase (LDC) and tyrosine decarboxylase (TyDC) in maize seedlings infested by bird cherry-oat aphid (Rhopalosiphum padi L.). Obtained results showed that the aphid infestation induced LDC activity strongly within tissues of less aphid-settled maize (Waza cv.) during the first week of the infestation in comparison to the control plants and the activity was suppressed after two weeks. However, TyDC activity fluctuated under the aphid infestation. In relation to the control, the enzyme activity was inhibited on the first day, activated after the first week and reduced again two weeks into the experiment. A significant reduction in ODC activity was also observed in seedlings of aphid-infested maize Waza cv. during the first week. In a more susceptible maize cv. (Złota Karłowa), an increase in LDC and TyDC activities in relation to the control and a simultaneous decrease in ODC activity were noted after the first day of the infestation. After one week of aphid attack, TyDC activity was induced and ODC was inhibited, whereas after two weeks ODC activity was decreased with a simultaneous increase in LDC activity in the Złota Karłowa seedlingsRhopalosiphum padiRhopalosiphum padidekarboksylazy aminokwasówamino acid decarboxylasesaminokwasyamino acidsaminy biogenne roślinplant biogenic amines : Agnieszka : Marta : Agnieszka : 999999 : 009999.000 : Z : 003 : Vol. 60 : OTHER Szczegóły: Miejsce wydania: KozakChwedczukKlewek998899009999.000001Changes in amino acid decarboxylation in maize (Zea mays; Poaceae) tissues in response to bird cherry-oat aphid (Rhopalosiphum padi; Aphididae) infestationBiochemical Systematics and Ecology20150305-197810.1016/j.bse.2015.04.017kukurydzamaizeKopia dostępna w Sekcji BibliometriiFINAL_PUB Wydawca: AgnieszkaMartaAgnieszka999999009999.000Z003Vol. 60 Rok wydania: 015009999.0002017-08-11, 09:59 Charakterystyka formalna: 0000002662AOartykuł oryginalny naukowyPUBLIKACJAPEŁNA PUBLIKACJAENGhttp://www.sciencedirect.com/science/journal/03051978/60?sdc=1PRACA RECENZOWANA100^bZ^a001^b003^c2017-08-11, 09:59^d2018-11-05, 09:49^e3722939280^f3619999290^aChanges in amino acid decarboxylation in maize (Zea mays; Poaceae) tissues in response to bird cherry-oat aphid (Rhopalosiphum padi; Aphididae) infestation^aBiochemical Systematics and Ecology^a2015^bVol. 60^dp. 158--164^a0305-1978^a10.1016/j.bse.2015.04.017^akukurydza^amaize^aKopia dostępna w Sekcji Bibliometrii^aFINAL_PUBLISHED^bOTHER^cAT_PUBLICATION^eOPEN_JOURNAL^aThe study was focused on changes in the activities of ornithine decarboxylase (ODC), lysine decarboxylase (LDC) and tyrosine decarboxylase (TyDC) in maize seedlings infested by bird cherry-oat aphid (Rhopalosiphum padi L.). Obtained results showed that the aphid infestation induced LDC activity strongly within tissues of less aphid-settled maize (Waza cv.) during the first week of the infestation in comparison to the control plants and the activity was suppressed after two weeks. However, TyDC activity fluctuated under the aphid infestation. In relation to the control, the enzyme activity was inhibited on the first day, activated after the first week and reduced again two weeks into the experiment. A significant reduction in ODC activity was also observed in seedlings of aphid-infested maize Waza cv. during the first week. In a more susceptible maize cv. (Złota Karłowa), an increase in LDC and TyDC activities in relation to the control and a simultaneous decrease in ODC activity were noted after the first day of the infestation. After one week of aphid attack, TyDC activity was induced and ODC was inhibited, whereas after two weeks ODC activity was decreased with a simultaneous increase in LDC activity in the Złota Karłowa seedlings^aRhopalosiphum padi^aRhopalosiphum padi^adekarboksylazy aminokwasów^aamino acid decarboxylases^aaminokwasy^aamino acids^aaminy biogenne roślin^aplant biogenic amines Praca recenzowana Słowa kluczowe ang.: lwia^pGoławska Sylwia^rGoławska^sSylwia^u^t^qGoławska S^w^x0000024890^zGoławska Sylwia^aKozak Słowa kluczowe: ; Słowa kluczowe ang.: ; Inne bazy podające opis:
662AOartykuł oryginalny naukowyPUBLIKACJAPEŁNA PUBLIKACJAENGhttp://www.sciencedirect.com/science/journal/03051978/60?sdc=1PRACA RECENZOWANA100^bZ^a001^b003^c2017-08-11, 09:59^d2018-11-05, 09:49^e3722939280^f3619999290^aChanges in amino acid decarboxylation in maize (Zea mays; Poaceae) tissues in response to bird cherry-oat aphid (Rhopalosiphum padi; Aphididae) infestation^aBiochemical Systematics and Ecology^a2015^bVol. 60^dp. 158--164^a0305-1978^a10.1016/j.bse.2015.04.017^akukurydza^amaize^aKopia dostępna w Sekcji Bibliometrii^aFINAL_PUBLISHED^bOTHER^cAT_PUBLICATION^eOPEN_JOURNAL^aThe study was focused on changes in the activities of ornithine decarboxylase (ODC), lysine decarboxylase (LDC) and tyrosine decarboxylase (TyDC) in maize seedlings infested by bird cherry-oat aphid (Rhopalosiphum padi L.). Obtained results showed that the aphid infestation induced LDC activity strongly within tissues of less aphid-settled maize (Waza cv.) during the first week of the infestation in comparison to the control plants and the activity was suppressed after two weeks. However, TyDC activity fluctuated under the aphid infestation. In relation to the control, the enzyme activity was inhibited on the first day, activated after the first week and reduced again two weeks into the experiment. A significant reduction in ODC activity was also observed in seedlings of aphid-infested maize Waza cv. during the first week. In a more susceptible maize cv. (Złota Karłowa), an increase in LDC and TyDC activities in relation to the control and a simultaneous decrease in ODC activity were noted after the first day of the infestation. After one week of aphid attack, TyDC activity was induced and ODC was inhibited, whereas after two weeks ODC activity was decreased with a simultaneous increase in LDC activity in the Złota Karłowa seedlings^aRhopalosiphum padi^aRhopalosiphum padi^adekarboksylazy aminokwasów^aamino acid decarboxylases^aaminokwasy^aamino acids^aaminy biogenne roślin^aplant biogenic amines
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Nr opisu: Autorzy: . Tytuł równoległy: Strony: 001Effect of selected flavonoids on the behavior of the bird cherry-oat aphid (Rhopalosiphum padi L.) during the colonization of winter wheatWpływ wybranych flawonoidów na zachowanie mszycy czeremchowo-zbożowej (Rhopalosiphum padi L.) podczas zasiedlania pszenicy ozimejProgress in Plant Protection / Postępy w Ochronie Roślin20151427-433710.14199/ppp-2015-033flawonoidyflavonoidsKopia dostępna w Sekcji BibliometriiFINAL_PUBLISHEDThe aim of the study was to determine the effects of such flavonoids as: apigenin, luteolin, quercetin, mirycetin, (+)-catechin and (-)-epicatechin on the behavior of wingless females and larvae of bird cherry-oat aphid (Rhopalosiphum padi L.) during the colonization of winter wheat seedlings. All the tested compounds showed deterrence activity against thebird cherry-oat aphid morphs. Significant differences in influence of tested flawonoids on behavior of wingless females and larvae were observed. Generally, wingless females were more susceptible than larvae. (-)-Epicatechin and quercetin were the most effective in relation to the wingless females and apigenin and (+)-catechin strongest modified larvae colonization behavior., 003, Vol. 55, CC-BY, 2017-08-11, 10:27, No. 2, AT_PUBLICATION, 2018-11-05, 09:50, p. 202--206 Charakterystyka formalna: Charakterystyka merytoryczna: Praca recenzowana Słowa kluczowe: Słowa kluczowe ang.: ; Streszczenie: Streszczenie: