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Bibliografia publikacji pracowników
Państwowej Szkoły Wyższej w Białej Podlaskiej

Baza tworzona przez Bibliotekę Akademii Bialskiej im. Jana Pawła II.


Zapytanie: GARBACZ ALEKSANDRA
Liczba odnalezionych rekordów: 2



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Autorzy: , , .
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Tytuł pracy w innym języku: Bertrandtoriginal-article998899009999.0001660-4601003The Influence of FTO, FABP2, LEP, LEPR, and MC4R Genes on Obesity Parameters in Physically Active Caucasian MenInternational Journal of Environmental Research and Public Health20221660-46012021/202210.3390/ijerph19106030Bertrandt, JerzyCaucasian menFINAL_PUBLISHEDObesity is a complex multifactorial abnormality that has a well-confirmed genetic basis. However, the problem still lies in identifying the polymorphisms linked to body mass and composition. Therefore, this study aimed to analyze associations between FTO (rs9939609), FABP2 (rs1799883), and LEP (rs2167270), LEPR (rs1137101), and MC4R (rs17782313) polymorphisms and obesity-related parameters. Unrelated Caucasian males (n = 165) were recruited. All participants had similar physical activity levels. The participants were divided into two groups depending on their body mass index (BMI) and fat mass index (FMI). All samples were genotyped using real-time polymerase chain reaction (real-time PCR). When tested individually, only one statistically significant result was found. The FTO A/T polymorphism was significantly associated with FMI (p = 0.01). The chance of having increased FMI was >2-fold higher for the FTO A allele carriers (p < 0.01). Gene-gene interaction analyses showed the additional influence of all investigated genes on BMI and FMI. In summary, it was demonstrated that harboring the FTO A allele might be a risk factor for elevated fat mass. Additionally, this study confirmed that all five polymorphisms are involved in the development of common obesity in the studied population and the genetic risk of obesity is linked to the accumulation of numerous variants.genesobesity-related traitsobesity riskphysical activitySNPs : Anna : Jerzy Władysław : Oryginalny artykuł naukowyACZartykuł w czasopiśmie zagranicznym : 998599140.0000140.000PUNKTACJA KBNPUNKTACJA MINISTERSTWALISTA FILADELFIJSKAIMPACT FACTOR140.000PUNKTACJA UWM : 009859.000 : Q : 003 : Vol. 19 : CC-BY
ISBN: Bertrandtoriginal-article
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Nr opisu: nna^u^t^qCywińska A^w^x0000032801^zCywińska Anna^aBorecka
Autorzy: , , , , .
Tytuł czasopisma:
Tytuł równoległy: BoreckaGarbaczSzarskaDziudaLorenzŁakomyLepionkaAnyżewskaBiałekBertrandtoriginal-article994294009994.3940860-021X003Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active menBiology of Sport20210860-021X2021/202210.5114/biolsport.2022.109957Bertrandt, JerzyBody Mass IndexFINAL_PUBLISHEDPeroxisome proliferator-activated receptors (PPARs) have unique functions in energy metabolism regulation but are also involved in regulation of the inflammatory process and obesity. The aim of this study was to analyse potential associations between polymorphisms of PPARA (rs1800206), PPARD (rs1053049; rs2267668) and PPARG (rs1801282) and overweight parameters. One hundred and sixty-six males, unrelated Caucasian military professionals, were recruited in the genetic case-control study conducted in the period 2016-2019. All the participants were aged 21-41 and had similar levels of physical activity. Body mass, height and body composition were measured. The participants were divided into two groups depending on their BMI (body mass index) and FMI (fat mass index). The control group consisted of people with BMI between 20.0 and 25.0 or FMI values ? 6, while the overweight group consisted of people with BMI of ? 25.0 or FMI values > 6. Genomic DNA was isolated from extracted buccal cells. All samples were genotyped using real-time polymerase chain reaction (real-time PCR). It was found that two polymorphisms rs2267668 and rs1053049 of the PPARD gene were significantly associated with BMI: SNP rs2267668 for the dominant (OR = 2.04, 95%CI 1.01-4.11, p-value = 0.04) model (A/G-G/G vs A/A). The likelihood of being overweight was over 2 times smaller for allele A. A relationship between the polymorphism of PPARG (rs1801282) and BMI was found for the overdominant (OR = 2.03, 95%CI 1.03-4.00, p-value = 0.04) model (C/G vs C/C-G/G). Significant associations were found in different models for PPARD, PPARG and PPARA genes with BMI. In SNP rs2267668 for the codominant genetic model (G/G vs A/A) (p-value = 0.04) and : Anna : Aleksandra : Ewa : Łukasz : Katarzyna : Roman : Tomasz : Anna : Agnieszka : Jerzy Władysław : Oryginalny artykuł naukowyACPartykuł w czasopiśmie polskim4.606IF : 998599140.0000140.000PUNKTACJA KBNPUNKTACJA MINISTERSTWALISTA FILADELFIJSKAIMPACT FACTOR140.000PUNKTACJA UWM : 009859.000 : Q : 003 : Vol. 38 : 2083-1862 : CC-BY-SA
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Słowa kluczowe: cka Anna^bAnna^c^d^e^f^g^h^i ^m_^n_^oBorecka Anna^pBorecka Anna^rBorecka^sAnna^u^t^qBorecka A^w^x0000017549^zBorecka Anna^aGarbacz
Słowa kluczowe ang.: pionka Tomasz^bTomasz^c^d^e^f^g^h^i ^m_^n_^oLepionka Tomasz^pLepionka Tomasz^rLepionka^sTomasz^u^t^qLepionka T^w^x0000032446^zLepionka Tomasz^aAnyżewska
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