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Bibliografia publikacji pracowników
Państwowej Szkoły Wyższej w Białej Podlaskiej

Baza tworzona przez Bibliotekę Akademii Bialskiej im. Jana Pawła II.


Zapytanie: KUBICK NORWIN
Liczba odnalezionych rekordów: 2



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Nr opisu: 0000046416
Autorzy: Norwin Kubick, Justyna Paszkiewicz, Irmina Bieńkowska, Michał Ławiński, Jarosław Olav Horbańczuk, Mariusz Sacharczuk, Michel Edward Mickael.
Tytuł pracy: Investigation of Mutated in Colorectal Cancer (MCC) Gene Family Evolution History Indicates a Putative Role in Th17/Treg Differentiation
Tytuł czasopisma:
Szczegóły: 2023, Vol. 24, issue 15, article number 11940
p-ISSN: 1422-0067
Charakterystyka formalna: artykuł w czasopiśmie zagranicznym
Charakterystyka merytoryczna: artykuł oryginalny naukowy
Charakterystyka wg MNiSW: artykuł w czasopiśmie z IF (wykaz MEiN)
Język publikacji: ENG
Wskaźnik Impact Factor ISI: 5.600
Punktacja ministerstwa: 140.000
Słowa kluczowe ang.: colorectal cancer ; differentiation ; evolution ; Th17 ; Treg
https://www.mdpi.com/1422-0067/24/15/11940
DOI: 10.3390/ijms241511940
Streszczenie: The MCC family of genes plays a role in colorectal cancer development through various immunological pathways, including the Th17/Treg axis. We have previously shown that MCC1 but not MCC2 plays a role in Treg differentiation. Our understanding of the genetic divergence patterns and evolutionary history of the MCC family in relation to its function, in general, and the Th17/Treg axis, in particular, remains incomplete. In this investigation, we explored 12 species' genomes to study the phylogenetic origin, structure, and functional specificity of this family. In vertebrates, both MCC1 and MCC2 homologs have been discovered, while invertebrates have a single MCC homolog. We found MCC homologs as early as Cnidarians and Trichoplax, suggesting that the MCC family first appeared 741 million years ago (Ma), whereas MCC divergence into the MCC1 and MCC2 families occurred at 540 Ma. In general, we did not detect significant positive selection regulating MCC evolution. Our investigation, based on MCC1 structural similarity, suggests that they may play a role in the evolutionary changes in Tregs' emergence towards complexity, including the ability to utilize calcium for differentiation through the use of the EFH calcium-binding domain. We also found that the motif NPSTGE was highly conserved in MCC1, but not in MCC2. The NPSTGE motif binds KEAP1 with high affinity, suggesting an Nrf2-mediated function for MCC1. In the case of MCC2, we found that the "modifier of rudimentary" motif is highly conserved. This motif contributes to the regulation of alternative splicing. Overall, our study sheds light on how the evolution of the MCC family is connected to its function in regulating the Th17/Treg axis.
Projekt/grant: Wpływ endogennego rozszczelnienia bariery krew-mózg w patogenezie zróżnicowanej podatności na inokulowanego czerniaka u linii myszy selekcjonowanych w kierunku wysokiej i niskiej analgezji postresowej : Akademia Bialska im. Jana Pawła II w ramach Regulaminu wsparcia rozwoju zawodowego pracowników, PB/5/2022

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Nr opisu: 0000044765
Autorzy: Suniti Bhumik, Marzena Łazarczyk, Norwin Kubick, Pavel Klimovich, Agata Gurba, Justyna Paszkiewicz, Patrycja Teodorowicz, Tomasz Kocki, Jarosław Olav Horbańczuk, Gina Manda, Mariusz Sacharczuk, Michel-Edwar Mickael.
Tytuł pracy: Investigation of the Molecular Evolution of Treg Suppresion Mechanisms Indicates a Covergent Origin
Tytuł czasopisma:
Szczegóły: 2023, Vol. 45, issue 1, p. 628--648
p-ISSN: 1467-3045
Charakterystyka formalna: artykuł w czasopiśmie zagranicznym
Charakterystyka merytoryczna: artykuł oryginalny naukowy
Charakterystyka wg MNiSW: artykuł w czasopiśmie z IF (wykaz MEiN)
Język publikacji: ENG
Wskaźnik Impact Factor ISI: 3.100
Punktacja ministerstwa: 70.000
Słowa kluczowe ang.: ai ; evolution ; molecular evolution ; tregs
https://www.mdpi.com/1467-3045/45/1/42
DOI: 10.3390/cimb45010042
Streszczenie: Regulatory T cell (Treg) suppression of conventional T cells is a central mechanism that ensures immune system homeostasis. The exact time point of Treg emergence is still disputed. Furthermore, the time of Treg-mediated suppression mechanisms' emergence has not been identified. It is not yet known whether Treg suppression mechanisms diverged from a single pathway or converged from several sources. We investigated the evolutionary history of Treg suppression pathways using various phylogenetic analysis tools. To ensure the conservation of function for investigated proteins, we augmented our study using nonhomology-based methods to predict protein functions among various investigated species and mined the literature for experimental evidence of functional convergence. Our results indicate that a minority of Treg suppressor mechanisms could be homologs of ancient conserved pathways. For example, CD73, an enzymatic pathway known to play an essential role in invertebrates, is highly conserved between invertebrates and vertebrates, with no evidence of positive selection (w = 0.48, p-value < 0.00001). Our findings indicate that Tregs utilize homologs of proteins that diverged in early vertebrates. However, our findings do not exclude the possibility of a more evolutionary pattern following the duplication degeneration-complementation (DDC) model. Ancestral sequence reconstruction showed that Treg suppression mechanism proteins do not belong to one family; rather, their emergence seems to follow a convergent evolutionary pattern.

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