Bibliografia publikacji pracowników
Państwowej Szkoły Wyższej w Białej Podlaskiej
Baza tworzona przez Bibliotekę Akademii Bialskiej im. Jana Pawła II.
Zapytanie:
MATUSKA KATARZYNA Liczba odnalezionych rekordów: 4
Przejście do opcji zmiany formatu | Wyświetl/ukryj etykiety | Wyświetlenie wyników w wersji do druku | Pobranie pliku do edytora | Nowe wyszukiwanie Streszczenie: Objectives: The aim of the study was to analyze some metalloproteinases, cytokines, and chemokines in LB patients and healthy seropositive subjects. The presence of IgM/IgG antibodies against specific Borreliella antigens was analyzed in the presence or absence of clinical manifestations of LB. Material and methods: The study involved 38 patients diagnosed with LB and arthralgia and/or arthritis symptoms, and 57 foresters presenting no clinical symptoms of LB. The ELISA test was applied for general screening of anti-Borreliella IgM/IgG. Western blot was used for confirmatory diagnosis of LB for the positive and borderline results. Serum IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-?, TNF, IL-8, CCL5, CXCL9/MIG, CCL2/MCP-1, CXCL10/IP-10 concentrations were measured with the use of the Human Cytometric CBA test. The concentration of MMP-2 and MMP-9 in the serum was determined with the use of ELISA tests. Results: Analysis of the cytokines and chemokines revealed that only the concentration of IL-2 was significantly higher (2.4 pg/m; p=0.00641) in patients with LB symptoms than in the seropositive individuals (0.4 pg/ml). The MMP2 concentration was significantly higher (233.3 ng/ml; p=0.00294) in patients with clinical manifestations of LB than in those occupationally exposed to tick bites, but did not have anti-Borreliella antibodies (192.0 ng/ml). Conclusions: The presence of IgG antibodies against a number of Borreliella antigens and the differences in the IL-2 and MMP2 levels in seropositive or seronegative individuals and symptomatic LB patients, may indicate differences in the intensity of the immune response to the infection and, consequently, may induce development of clinical manifestations of the disease in seropositive and seronegative individuals. Projekt/grant: Borrelia burgdorferi u pacjentów kwalifikowanych i leczonych z powodu boreliozy : Fundusz Grantów na Badania Własne / PSW Biała Podlaska, grant numer IV Projekt/grant: Analiza profilu wydzielania wybranych cytokin i chemokin u pacjentów leczonych z powodu boreliozy z Lyme : działalność statutowa WNZS PSW, S/11/17
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Nr opisu: 0000041033 Autorzy: Małgorzata Tokarska-Rodak, Hanna Fota-Markowska, Anna Pańczuk, Katarzyna Matuska, Marta Zarębska. Tytuł pracy: Analysis of the concentration of selected serological parameters in patients undergoing antibiotic treatment of Lyme disease and assessment of their potential application in the control of the therapy effectiveness - pilot study Tytuł czasopisma: Szczegóły: 2021, Vol. 28, no. 4, p. 605--611 p-ISSN: 1232-1966 e-ISSN: 1898-2263 Charakterystyka formalna: artykuł w czasopiśmie polskim Charakterystyka merytoryczna: artykuł oryginalny naukowy Charakterystyka wg MNiSW: artykuł w czasopiśmie z IF (wykaz MEiN) Język publikacji: ENG Wskaźnik Impact Factor ISI: 1.603 Punktacja ministerstwa: 100.000 Słowa kluczowe ang.: cytokines ; chemokines ; metalloproteinases ; Lyme borreliosis ; Borreliella spp ; anti-C6VIsE IgG http://www.aaem.pl/Analysis-of-the-concentration-of-selected-serological-parameters-in-patients-undergoing,132786,0,2.html DOI: 10.26444/aaem/132786 Streszczenie: Objective: The aim of the study was to analyze the concentrations of some serological parameters in patients undergoing antibiotic therapy for LD, and to assess the potential use of IgG anti-C6VlsE in the assessment of treatment effectiveness. Material and methods: The study involved 21 patients diagnosed with LD. To determine the levels of anti-C6VlsE IgG, metalloproteinases and cytokines, blood was collected three times: before treatment, immediately after treatment, and 3-4 months after treatment. Results: Immediately after the antibiotic therapy, all the patients in the study group declared improvement in their health. At 3-4 months post-treatment, 50% of patients reported recurrence of the disease symptoms. The anti-C6VlsE IgG concentrations at the analyzed time points exhibited varied dynamics: in 15% of patients, a decrease in the concentration of anti-C6VlsE was observed in the three consecutive serum samples; an increase of anti-C6VlsE IgG was detected in 35% of cases; in 15% of the subjects, the concentration of anti-C6VlsE IgG increased immediately after the antibiotic therapy and declined after 3-4 months, whereas a reverse situation was noted in 10% of the patients. Conclusions: The presence of high concentrations of anti-C6VlsE IgG is associated with appearance of response to Borreliella spp. infection, which suggests that the parameter can be used in the diagnosis of the active form of borreliosis. However, from a practical point of view, a marker of successful elimination of infection should indicate the effectiveness or failure of antibiotic therapy within a relatively short post-treatment period. The anti-C6VlsE IgG antibodies do not seem to satisfy this provision. Projekt/grant: Analiza odpowiedzi immunologicznej na zakażenia Borrelia burgdorferi u pacjentów kwalifikowanych i leczonych z powodu boreliozy : Fundusz Grantów na Badania Własne / PSW Biała Podlaska, edycja IV Projekt/grant: Analiza profilu wydzielania wybranych cytokin i chemokin u pacjentów leczonych z powodu boreliozy z Lyme : działalność statutowa WNZS PSW, S/11/2017